Advertisement
Review Article| Volume 3, P227-237, September 2021

Download started.

Ok

Arterial Spin Labeling Applications in Neuroimaging

Emerging Use in Head and Neck Imaging
      Arterial spin labeling (ASL) is clinically available on all major MRI platforms and has utility in intracranial and extracranial neuroimaging applications.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Advances in Clinical Radiology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Detre J.A.
        • Leigh J.S.
        • Williams D.S.
        • et al.
        Perfusion imaging.
        Magn Reson Med. 1992; 23: 37-45
        • Alsop D.C.
        • Detre J.A.
        • Golay X.
        • et al.
        Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: a consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia.
        Magn Reson Med. 2015; 73: 102-116
        • Steketee R.M.E.
        • Mutsaerts H.J.M.M.
        • Bron E.E.
        • et al.
        Quantitative Functional Arterial Spin Labeling (fASL) MRI – sensitivity and reproducibility of regional CBF changes using pseudo-continuous ASL product sequences.
        PLoS One. 2015; 10: e0132929
        • Hernandez-Garcia L.
        • Lahiri A.
        • Schollenberger J.
        Recent progress in ASL.
        NeuroImage. 2019; 187: 3-16
        • Amukotuwa S.A.
        • Yu C.
        • Zaharchuk G.
        3D Pseudocontinuous arterial spin labeling in routine clinical practice: a review of clinically significant artifacts.
        J Magn Reson Imaging. 2016; 43: 11-27
        • Amukotuwa S.A.
        • Marks M.P.
        • Zaharchuk G.
        • et al.
        Arterial spin-labeling improves detection of intracranial dural arteriovenous fistulas with MRI.
        AJNR Am J Neuroradiol. 2018; 39: 669-677
        • Haller S.
        • Zaharchuk G.
        • Thomas D.L.
        • et al.
        Arterial spin labeling perfusion of the brain: emerging clinical applications.
        Radiology. 2016; 281: 337-356
        • Narayanan S.
        • Schmithorst V.
        • Panigrahy A.
        Arterial spin labeling in pediatric neuroimaging.
        Semin Pediatr Neurol. 2020; 33: 100799
        • Ho M.-L.
        Arterial spin labeling: clinical applications.
        J Neuroradiol. 2018; 45: 276-289
        • Bambach S.
        • Smith M.
        • Morris P.P.
        • et al.
        Arterial spin labeling applications in pediatric and adult neurologic disorders.
        J Magn Reson Imaging. 2020; ([Epub ahead of print])
        • Ye F.Q.
        • Berman K.F.
        • Ellmore T.
        • et al.
        H215O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans.
        Magn Reson Med. 2000; 44: 450-456
        • Lassen N.A.
        Normal average value of cerebral blood flow in younger adults is 50 ml/100 g/min.
        J Cereb Blood Flow Metab. 1985; 5: 347-349
        • Clement P.
        • Mutsaerts H.-J.
        • Václavů L.
        • et al.
        Variability of physiological brain perfusion in healthy subjects – A systematic review of modifiers. Considerations for multi-center ASL studies.
        J Cereb Blood Flow Metab. 2018; 38: 1418-1437
        • Zaharchuk G.
        Arterial spin–labeled perfusion imaging in acute ischemic stroke.
        Stroke. 2014; 45: 1202-1207
        • Nael K.
        • Meshksar A.
        • Liebeskind D.S.
        • et al.
        Periprocedural arterial spin labeling and dynamic susceptibility contrast perfusion in detection of cerebral blood flow in patients with acute ischemic syndrome.
        Stroke. 2013; 44: 664-670
        • Belani P.
        • Kihira S.
        • Pacheco F.
        • et al.
        Addition of arterial spin-labelled MR perfusion to conventional brain MRI: clinical experience in a retrospective cohort study.
        BMJ Open. 2020; 10: e036785
        • Zaharchuk G.
        Arterial spin label imaging of acute ischemic stroke and transient ischemic attack.
        Neuroimaging Clin N Am. 2011; 21: 285-301
        • Di Napoli A.
        • Cheng S.F.
        • Gregson J.
        • et al.
        Arterial spin labeling MRI in carotid stenosis: arterial transit artifacts may predict symptoms.
        Radiology. 2020; 297: 652-660
        • Zaharchuk G.
        Arterial transit awesomeness.
        Radiology. 2020; 297: 661-662
        • Helton K.J.
        • Paydar A.
        • Glass J.
        • et al.
        Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia.
        Pediatr Blood Cancer. 2009; 52: 85-91
        • Yeom K.W.
        • Lober R.M.
        • Barnes P.D.
        • et al.
        Reduced cerebral arterial spin-labeled perfusion in children with neurofibromatosis type 1.
        AJNR Am J Neuroradiol. 2013; 34: 1823-1828
        • Mamlouk M.D.
        • Vossough A.
        • Caschera L.
        • et al.
        Arterial spin-labeling perfusion for PHACE syndrome.
        AJNR Am J Neuroradiol. 2021; 42: 173-177
        • Quon J.L.
        • Kim L.H.
        • Lober R.M.
        • et al.
        Arterial spin-labeling cerebral perfusion changes after revascularization surgery in pediatric moyamoya disease and syndrome.
        J Neurosurg Pediatr. 2019; 23: 486-492
        • Burns R.
        • De Malherbe M.
        • Chadenat M.-L.
        • et al.
        Arterial spin-labeled MR imaging detecting biphasic neurovascular changes in migraine with persistent aura.
        Headache. 2017; 57: 1627-1628
        • Lam J.
        • Tomaszewski P.
        • Gilbert G.
        • et al.
        The utility of arterial spin labeling in the presurgical evaluation of poorly defined focal epilepsy in children.
        J Neurosurg Pediatr. 2020; 27: 1-10
        • Lee S.M.
        • Kwon S.
        • Lee Y.J.
        Diagnostic usefulness of arterial spin labeling in MR negative children with new onset seizures.
        Seizure. 2019; 65: 151-158
        • Telischak N.A.
        • Detre J.A.
        • Zaharchuk G.
        Arterial spin labeling MRI: clinical applications in the brain.
        J Magn Reson Imaging. 2015; 41: 1165-1180
        • Sachs J.R.
        • Zapadka M.E.
        • Popli G.S.
        • et al.
        Arterial spin labeling perfusion imaging demonstrates cerebral hyperperfusion in anti-NMDAR encephalitis.
        Radiol Case Rep. 2017; 12: 833-837
        • Fällmar D.
        • Haller S.
        • Lilja J.
        • et al.
        Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
        Eur Radiol. 2017; 27: 4237-4246
        • Chen Y.
        • Wolk D.A.
        • Reddin J.S.
        • et al.
        Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease.
        Neurology. 2011; 77: 1977-1985
        • Musiek E.S.
        • Chen Y.
        • Korczykowski M.
        • et al.
        Direct comparison of fluorodeoxyglucose positron emission tomography and arterial spin labeling magnetic resonance imaging in Alzheimer's disease.
        Alzheimers Dement. 2012; 8: 51-59
        • Alexopoulos P.
        • Sorg C.
        • Förschler A.
        • et al.
        Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer’s disease measured by pulsed arterial spin labeling MRI.
        Eur Arch Psychiatry Clin Neurosci. 2012; 262: 69-77
        • Riederer I.
        • Bohn K.P.
        • Preibisch C.
        • et al.
        Alzheimer disease and mild cognitive impairment: integrated pulsed arterial spin-labeling MRI and 18F-FDG PET.
        Radiology. 2018; 288: 198-206
        • Tosun D.
        • Schuff N.
        • Rabinovici G.D.
        • et al.
        Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.
        Ann Clin Transl Neurol. 2016; 3: 740-751
        • Dolui S.
        • Li Z.
        • Nasrallah I.M.
        • et al.
        Arterial spin labeling versus (18)F-FDG-PET to identify mild cognitive impairment.
        Neuroimage Clin. 2020; 25: 102146
        • Xu Q.
        • Liu Q.
        • Ge H.
        • et al.
        Tumor recurrence versus treatment effects in glioma: a comparative study of three dimensional pseudo-continuous arterial spin labeling and dynamic susceptibility contrast imaging.
        Medicine. 2017; 96: e9332
        • Yamashita K.
        • Yoshiura T.
        • Hiwatashi A.
        • et al.
        Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and 18F-fluorodeoxyglucose positron emission tomography.
        Neuroradiology. 2013; 55: 135-143
        • Dangouloff-Ros V.
        • Deroulers C.
        • Foissac F.
        • et al.
        Arterial spin labeling to predict brain tumor grading in children: correlations between histopathologic vascular density and perfusion MR imaging.
        Radiology. 2016; 281: 553-566
        • Mayercik V.
        • Ma M.
        • Holdsworth S.
        • et al.
        Arterial spin-labeling MRI identifies hypervascular meningiomas.
        AJR Am J Roentgenol. 2019; 213: 1124-1128
        • Mamlouk M.D.
        • Hess C.P.
        Arterial spin-labeled perfusion for vascular anomalies in the pediatric head and neck.
        Clin Imaging. 2016; 40: 1040-1046
        • Boulouis G.
        • Dangouloff-Ros V.
        • Boccara O.
        • et al.
        Arterial spin-labeling to discriminate pediatric cervicofacial soft-tissue vascular anomalies.
        AJNR Am J Neuroradiol. 2017; 38: 633-638
        • Kleijwegt M.C.
        • Van Der Mey A.G.L.
        • Wiggers-Debruine F.T.
        • et al.
        Perfusion magnetic resonance imaging provides additional information as compared to anatomical imaging for decision-making in vestibular schwannoma.
        Eur J Radiol Open. 2016; 3: 127-133
        • Tanaka Y.
        • Kohno M.
        • Hashimoto T.
        • et al.
        Arterial spin labeling imaging correlates with the angiographic and clinical vascularity of vestibular schwannomas.
        Neuroradiology. 2020; 62: 463-471
        • Fujima N.
        • Nakamaru Y.
        • Sakashita T.
        • et al.
        Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR perfusion imaging.
        Dentomaxillofac Radiol. 2015; 44: 20150074
        • Eissa L.
        • Abdel Razek A.A.K.
        • Helmy E.
        Arterial spin labeling and diffusion-weighted MR imaging: utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma.
        Clin Imaging. 2020; 71: 63-68
        • Razek A.A.K.A.
        Multi-parametric MR imaging using pseudo-continuous arterial-spin labeling and diffusion-weighted MR imaging in differentiating subtypes of parotid tumors.
        Magn Reson Imaging. 2019; 63: 55-59
        • Lin M.
        • Yu X.
        • Luo D.
        • et al.
        Investigating the correlation of arterial spin labeling and dynamic contrast enhanced perfusion in primary tumor of nasopharyngeal carcinoma.
        Eur J Radiol. 2018; 108: 222-229
        • Fujima N.
        • Sakashita T.
        • Homma A.
        • et al.
        Glucose metabolism and its complicated relationship with tumor growth and perfusion in head and neck squamous cell carcinoma.
        PLoS One. 2016; 11: e0166236
        • Xu P.
        • Li Y.
        • Yang S.
        • et al.
        Positron emission tomographic imaging elucidates the complex relationship between glucose uptake and tissue blood flow mechanism in squamous cell oral cancer patients.
        Med Sci Monit. 2017; 23: 4533-4540
        • Li Y.
        • Li X.
        • Yu X.
        • et al.
        Investigating the value of arterial spin labeling and intravoxel incoherent motion imaging on diagnosing nasopharyngeal carcinoma in T1 stage.
        Cancer Imaging. 2020; 20: 62
        • Abdel Razek A.A.K.
        • Nada N.
        Arterial spin labeling perfusion-weighted MR imaging: correlation of tumor blood flow with pathological degree of tumor differentiation, clinical stage and nodal metastasis of head and neck squamous cell carcinoma.
        Eur Arch Otorhinolaryngol. 2018; 275: 1301-1307
        • Razek A.A.K.A.
        • Helmy E.
        Multi-parametric arterial spin labeling and diffusion-weighted imaging in differentiation of metastatic from reactive lymph nodes in head and neck squamous cell carcinoma.
        Eur Arch Otorhinolaryngol. 2021; 278: 2529-2535
        • Fujima N.
        • Kudo K.
        • Tsukahara A.
        • et al.
        Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: comparison with dynamic contrast-enhanced MRI.
        J Magn Reson Imaging. 2015; 41: 983-991
        • Bisdas S.
        • Baghi M.
        • Wagenblast J.
        • et al.
        Differentiation of benign and malignant parotid tumors using deconvolution-based perfusion CT imaging: feasibility of the method and initial results.
        Eur J Radiol. 2007; 64: 258-265
        • Hirasawa S.
        • Tsushima Y.
        • Takei H.
        • et al.
        Inverse correlation between tumor perfusion and glucose uptake in human head and neck tumors.
        Acad Radiol. 2007; 14: 312-318
        • Fujima N.
        • Yoshida D.
        • Sakashita T.
        • et al.
        Usefulness of pseudocontinuous arterial spin-labeling for the assessment of patients with head and neck squamous cell carcinoma by measuring tumor blood flow in the pretreatment and early treatment period.
        AJNR Am J Neuroradiol. 2016; 37: 342-348
        • Truong M.T.
        • Saito N.
        • Ozonoff A.
        • et al.
        Prediction of locoregional control in head and neck squamous cell carcinoma with serial CT perfusion during radiotherapy.
        AJNR Am J Neuroradiol. 2011; 32: 1195-1201
        • Fujima N.
        • Kudo K.
        • Yoshida D.
        • et al.
        Arterial spin labeling to determine tumor viability in head and neck cancer before and after treatment.
        J Magn Reson Imaging. 2014; 40: 920-928
        • Abdel Razek A.A.K.
        Arterial spin labelling and diffusion-weighted magnetic resonance imaging in differentiation of recurrent head and neck cancer from post-radiation changes.
        J Laryngol Otol. 2018; 132: 923-928