The current standard treatment options for obesity include lifestyle modifications,
bariatric surgery, pharmacotherapy, endoscopic bariatric techniques, and a new interventional
radiologic method called bariatric embolization.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Advances in Clinical RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Health effects of overweight and obesity in 195 countries over 25 years.N Engl J Med. 2017; 377: 13-27
- Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old.N Engl J Med. 2006; 355: 763-778
- Defining adult overweight and obesity.(Available at:) (Accessed March 29, 2017)
- Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.Lancet. 2014; 384: 766-781
- Obesity management.in: Jordan W.H. Principles of human nutrition. HardPress Publishing, Miami (FL)2012: 788-801
- National Institutes of Health, and National Heart Lung and Blood Institute, Managing overweight and obesity in adults. Systematic evidence review from the obesity expert panel.(Available at:) (Accessed March 22, 2017)
- A lifestyle modification for obesity. New developments in diet, physical activity, and behavior therapy.Circulation. 2012; 125: 115-1170
- Physical activity and adults.(Available at:) (Accessed March 29, 2017)
- Managing obesity in primary care practice: a narrative review.Ann N Y Acad Sci. 2013; 1281: 191-206
- Mechanisms of weight regain following weight loss.ISRN Obes. 2013; 2013: 210524
- Obesity Surgery Indications And Contraindications.in: StatPearls. StatPearls Publishing, Treasure Island (FL)2020
- Bariatric surgery versus intensive medical therapy for diabetes - 5 year outcomes.N Engl J Med. 2017; 376: 641-651
- Jejunoileal bypass: a surgery of the past and a review of its complications.World J Gastroenterol. 2009; 14: 2277-2279
- Surgical treatment of obesity: a review.J Natl Med Assoc. 2004; 96: 61-75
- The surgical management of obesity.Gastroenterol Clin North Am. 2016; 45: 689-703
- Bariatric surgery for obesity and metabolic conditions in adults.BMJ. 2014; 349: g3961
- Gastric stimulation: a new paradigm for management of morbid obesity.Obes Surg. 2004; 14: S2
- Surgical treatment of obesity.Eur J Endocrinol. 2008; 158: 135-145
- Receptivity to bariatric surgery in qualified patients.J Obes. 2016; 2016: 5372190
- Impact of bariatric surgery on health care costs of obese persons: a 6 year follow up of surgical and comparison cohorts using health plan data.JAMA Surg. 2013; 148: 555-562
- Current pharmacotherapy for obesity.Nat Rev Endocrinol. 2018; 14: 12-24
- Interactions between the “cognitive” and “metabolic” brain in the control of food intake.Physiol Behav. 2007; 91: 486-498
- Evaluation of phentermine and topiramate versus phentermine/topiramate extended release in obese adults.Obesity. 2013; 21: 2163-2171
- Medical treatment of obesity: the past, the present and the future.Best Pract Res Clin Gastroenterol. 2014; 28: 665-684
- XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients.Diabetes Care. 2004; 27: 155-161
- Pharmacotherapy for the management of obesity.Metabolism. 2015; 64: 1376-1385
- Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study.Am J Clin Nutr. 2012; 95: 297-308
- Multicenter, placebo-controlled trial of lorcaserin for weight management.N Engl J Med. 2010; 363: 245-256
- Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study.Obesity (Silver Spring). 2012; 20: 1426-1436
- Pharmacotherapy for obesity.Endocrinol Metab Clin North Am. 2016; 45: 521-538
- A randomized, controlled trial of 3.0 mg of liraglutide in weight management.N Engl J Med. 2015; 373: 11-22
- Preface. Obesity and associated eating disorders: a guide for mental health professionals.Psychiatr Clin North Am. 2011; 34 (xiii–xvi)
- Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial.Obesity (Silver Spring, Md.). 2011; 19: 110-120
- Recent clinical results of endoscopic bariatric therapies as an obesity intervention.Clin Endosc. 2017; 50: 42-50
- Endoscopic treatments of obesity: a comprehensive review.Surg Obes Relat Dis. 2016; 12: 1108-1115
- Endoscopic bariatric therapies.Gastrointest Endosc. 2015; 81: 1073-1086
- SAGES review of endoscopic and minimally invasive bariatric interventions: a review of endoscopic and non-surgical bariatric interventions.Surg Endosc. 2018; 32: 4063-4067
- Weight loss and improved quality of life with a nonsurgical endoscopic treatment for obesity: clinical results from a 3- and 6-month study.Surg Obes Relat Dis. 2014; 10: 929-934
- Endoscopic sleeve gastroplasty: a potential endoscopic alternative to surgical sleeve gastrectomy for treatment of obesity.Gastrointest Endosc. 2013; 78: 530-535
- Endoscopic therapy for weight loss: gastroplasty, duodenal sleeves, intragastric balloons, and aspiration.World J Gastrointest Endosc. 2015; 7: 847-859
- 12 Month randomized sham controlled trial evaluating the safety and efficacy of targeted use of endoscopic suture anchors for primary obesity: The ESSENTIAL study.Gastroenterology. 2016; 150: S25-S26
- The effect of the endoscopic duodenal-jejunal bypass liner on obesity and type 2 diabetes mellitus, a multicenter randomized controlled trial.Ann Surg. 2014; 260: 984-992
- Recent trends in endoscopic management of obesity.Surg Innov. 2016; 23: 525-537
- A novel endoscopic weight loss therapy using gastric aspiration: results after 6 months.Endoscopy. 2015; 47: 68-71
- Changes in gastrointestinal hormones and leptin after Roux-en-Y gastric bypass surgery.JPEN J Parenter Enteral Nutr. 2011; 35: 169-180
- Clinical safety of bariatric arterial embolization: preliminary results of the BEAT obesity trial.Radiology. 2017; 283: 598-608
- Long-term persistence of hormonal adaptations to weight loss.N Engl J Med. 2011; 365: 1597-1604
- A preliminary observation of weight loss following left gastric artery embolization in humans.J Obes. 2014; 2014: 185349
- Ghrelin is a growth-hormone-releasing acylated peptide from stomach.Nature. 1999; 402: 656-660
- Gut hormones and appetite control.Gastroenterology. 2007; 132: 2116-2130
- Catheter-directed gastric artery chemical embolization for modulation of systemic ghrelin levels in a porcine model: initial experience.Radiology. 2007; 244: 138-143
- Catheter-directed gastric artery chemical embolization suppresses systemic ghrelin levels in porcine model.Radiology. 2008; 249: 127-133
- Histopathologic and immunohistochemical sequelae of bariatric embolization in a porcine model.J Vasc Interv Radiol. 2014; 25: 455-461
- Bariatric embolization for suppression of the hunger hormone ghrelin in a porcine model.Radiology. 2013; 266: 471-479
- Embolization of arterial gastric supply in obesity (EMBARGO): an endovascular approach in the management of morbid obesity. proof of the concept in the porcine model.Obes Surg. 2015; 25: 550-558
- Bariatric embolization of arteries for the treatment of obesity (BEAT obesity) trial: results at 1 year.Radiology. 2019; 291: 792-800
- Transradial left gastric artery embolization to treat severe obesity: a pilot study.Catheter Cardiovasc Interv. 2019; 93: 365-370
- Gastric embolization as treatment for overweight patients; efficacy and safety.Cardiovasc Intervent Radiol. 2019; 42: 513-519
- Bariatric embolization of the left gastric arteries for the treatment of obesity: 9-month data in 5 patients.Obes Surg. 2018; 28: 907-915
- Gastric artery embolization trial for the lessening of appetite nonsurgically (GET LEAN): six-month preliminary data.J Vasc Interv Radiol. 2016; 27: 1502-1508
- Endovascular bariatrics: first in humans study of gastric artery embolization for weight loss.JACC Cardiovasc Interv. 2015; 8: 161-164
- Weight loss after left gastric artery embolization: a systematic review and meta-analysis.J Vasc Interv Radiol. 2019; 30: 1593-1603.e3
Article info
Publication history
Published online: July 14, 2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.